With infection rates of Zika virus increasing rapidly, physicians should be prepared to handle cases of the virus and answer patients' questions. In the continental United States, Zika cases have been confirmed in returning travelers and infections through sexual transmission have been documented. The Florida Department of Health has concluded that a high likelihood exists that Zika virus infections are being caused by bites of local Aedes aegypti mosquitoes. As a result, a travel warning has been issued for the Wynwood and Miami Beach areas of Miami-Dade County, Florida. The AMA will update this resource center regularly to provide information to the public, physicians and other health care workers as they seek to learn more.
View CDC/AMA Webinar on Zika Virus
The CDC/AMA webinar "Preparing for Zika Transmission in the U.S." presented by the AMA in partnership with the Centers for Disease Control and Prevention (CDC) is now available for viewing. Listen to CDC Medical Epidemiologist Susan Hills, MBBS, MTH, present an update on the epidemiological and clinical aspects of the current outbreak. CDC Medical Officer Kiran Perkins, MD, MPH, presented on the implications for pregnant women, including CDC's updated interim clinical guidance, before fielding questions from webinar participants.
Updated Information on Zika Virus
The CDC Health Alert Network: CDC Expands Guidance for Travel and Testing of Pregnant Women, Women of Reproductive Age and Their Partners for Zika Virus Infection Related to Mosquito-Born Zika Virus Transmission in Miami-Dade, Florida.
The Centers for Disease Control and Prevention updated its recommendation for men with possible Zika virus exposure who are considering trying to conceive with their partners. The updated guidance recommends waiting at least 6 months to conceive after symptom onset or last possible Zika virus exposure (if asymptomatic). The recommendation is based on new scientific evidence and is consistent with the World Health Organization guidance.
Resources for the Public
What You Need to Know About Zika Virus
Information from the Centers for Disease Control and Prevention
Frequently Asked Questions About Zika Virus
Videos, fact sheets and other information from the World Health Organization (WHO) that explain what the virus is, which symptoms to look for and how to protect your family
Zika Virus Infection, Prevention and Recommendations for Pregnant Women
Infographics, frequently asked questions, interactive games and more from the Pan American Health Organization (PAHO) and WHO
Zika and Pregnancy
Latest information from the CDC for pregnant women
Information for Parents About Zika Virus
Latest information from the CDC for parents
Zika Virus Disease
Journal of the American Medical Association (JAMA) patient page from April 13
How to Protect Against Mosquito Bites (PDF)
Latest information from the CDC
World map and list of countries and territories with active Zika transmission, provided by the CDC
Resources for Physicians:
Understanding Zika Virus
Zika Virus Information for Health Care Professionals
Includes clinical evaluation and diagnostic testing information from the CDC
Interim CDC Zika Response Plan (PDF)
Initial response to Zika virus infections in continental U.S. and Hawaii
CDC Zika Action Plan Summit
Presentations and Resources from April 1
Zika and Pregnancy
CDC Vital Signs from April 1
CDC Changes Reporting of Numbers of Pregnant Women Affected by Zika Virus
CDC media statement from May 20
Male-to-male Sexual Transmission of Zika Virus—Texas, January 2016
CDC Morbidity and Mortality Weekly Report (MMWR) from April 15
Zika Virus Emergency Preparedness and Response
Latest information from the WHO
Zika Virus Infection
Information and resources from the PAHO and WHO
Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Persons with Possible Zika Virus Exposure — United States, September 2016
MMWR from Sept. 30
Diagnostic Testing of Urine Specimens for Suspected Zika Virus Infection
CDC Health Advisory from May 25
CPT Codes for Zika-related Imaging and Lab Test Procedures
Last updated April 15
Zika Virus—What Clinicians Need to Know
CDC webinar from Jan. 26
Interim Guidelines for Pregnant Women During a Zika Virus Outbreak
MMWR from Jan. 19
Possible Association Between Zika Virus Infection and Microcephaly
MMWR from Jan. 22
Medical Journal Articles
Low risk of a sexually-transmitted Zika virus outbreak
The Lancet from October 2016
Fast-Track Zika Vaccine Development — Is It Possible?
NEJM Perspective from Sept. 29
Considerations for Developing a Zika Virus Vaccine
NEJM Perspective from Sept. 29
Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears
Cell Reports, Washington University School of Medicine report from Sept. 6
Zika: Worse Than Thalidomide?
JAMA from Aug. 24
Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally
Radiology original research from Aug. 23
JAMA from Aug. 16
Zika Virus 6 Months Later
JAMA Viewpoints from Aug. 8
Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Science research Article from Aug. 4
Development and Implementation of a Zika Virus Disease Response Protocol at a Large Academic Medical Center
Disaster Medicine and Public Health Preparedness from July 19
Modeling Zika Virus Infection in Pregnancy
New England Journal of Medicine (NEJM) from Aug. 4
Zika and the Risk of Microcephaly
NEJM Perspectives from July 7
Pathology of Congenital Zika Syndrome in Brazil: a case series
The Lancet from June 29
Zika Virus and Birth Defects—Reviewing the Evidence for Causality
NEJM from May 19
More Evidence Linking Zika Virus to Birth Defects
JAMA Global Health published May 17
On the Seasonal Occurrence and Abundance of the Zika Virus Vector Mosquito Aedes Aegypti in the Contiguous United States
PLOS Current Outbreaks published March 16
Is the United States Prepared for a Major Zika Virus Outbreak?
JAMA Viewpoint published April 13
NEJM from March 30
Pregnancy in the Time of Zika: Addressing Barriers for Developing Vaccines and Other Measures for Pregnant Women
JAMA Viewpoint published March 22
Infectious Zika viral particles in breastmilk
Lancet Correspondence from March 1
Detection and Sequencing of Zika Virus From Amniotic Fluid of Fetuses With Microcephaly in Brazil: a Case Study
Lancet Infectious Disease from Feb. 17
"Pregnancy in the Time of Zika: Addressing Barriers for Developing Vaccines and Other Measures for Pregnant Women"
JAMA Viewpoint published Feb. 24
"Researchers Focus on Solving the Zika Riddles"
Commentary on establishing causality, vaccine research, and containment published in JAMA Feb. 24
"What Pediatricians and Other Clinicians Should Know About Zika Virus"
JAMA Pediatrics Viewpoint published Feb. 18
"Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil"
Significant new clinical data on the Zika virus and infants, published online in JAMA Ophthalmology, Feb. 9
"Zika Virus Infection and the Eye"
Commentary on ocular findings in infants, published online in JAMA Ophthalmology, Feb. 9
"The Emerging Zika Pandemic: Enhancing Preparedness"
JAMA Viewpoint published Jan. 27
"Anticipating the International Spread of Zika Virus From Brazil"
Published in The Lancet, Jan. 23
"Zika Virus in the Americas—Yet Another Arbovirus Threat"
Commentary published in The New England Journal of Medicine, Jan. 13 (e-publication ahead of print)
Potential Sexual Transmission of Zika Virus
CDC Emerging Infectious Diseases dispatch from Feb. 2015
Zika Virus Response Updates
Latest from FDA
FDA Allows Use of Investigational Test to Screen Blood Donations for Zika Virus
FDA press release from March 30
Interim Guidance for Protecting Workers From Occupational Exposure to Zika Virus (PDF)
OSHA and NIOSH guidance from April 22
NIH begins testing investigational Zika vaccine in humans
National Institutes of Health News Release from Aug. 3
Potential research priorities to inform public health and medical practice for domestic Zika virus: Workshop in brief
Institute of Medicine Workshop Summary from Feb. 16
Notice of NIAID’s interest to highlight high-priority Zika virus research areas
Research notice by the National Institutes of Health from Jan. 22