Recently there have been revisions in naming genetically modified cell-based therapies. In the past, these types of therapies were named as cellular therapies using the infix "-gen-" for cells that were transduced with a gene.
The Office of Cellular, Tissue and Gene Therapies (OCTGT) group of the FDA, the USAN Council and the INN agreed to use a 2-word naming scheme for genetically modified cell-based therapies. The first word is to be the same as the gene therapy first word for the gene. The second word suffix is "-cel" and a cell type infix is included before the "-cel" ending.
As shown below, both words will only contain one infix.
First Word: Corresponds to the Gene Component
Prefix: Random to contribute euphonious and distinctive name.
Infix: To identify the gene using existing infixes for biological products or using a similar infix for the protein for which the gene codes:
-ald- adrenoleukodystrophy (ALD) protein
-beglo- βA-t87Q-globin
-bermin- vascular endothelial growth factor
-cabta- cell expressed antibody and T cell activation
-cima- cytosine deaminase
-ermin- growth factor
-etid- eczema-throbocytopenia-immunodeficiency syndrome
-far- interferon
-fermin- fibroblast growth factor
-kin- interleukins
-lim- immunomodulator
-lip- human lipoprotein lipase
-mul- multiple genes
-naco- coagulation factor IX
-nad- NADH dehydrogenase
-nermin- tumor necrosis factor (TNF)
-octoco- coagulation factor Vlll
-pap- human papilloma virus
-papkino- human papilloma virus and IL-2
-permin- hepatocyte growth factor
-repi- REP-1 gene
-reti- retinal pigment
-semn- SMN
-stim- colony stimulating factor
-tima- thymidine kinase
-tusu- tumor suppression
Suffix: - (a vowel) gene: e.g., -(o)gene
Second Word: Corresponds to the Vector and Cell Component
Prefix: Random to contribute euphonious and distinctive name.
Infix: Cell type; reference USAN/INN infix for cell type:
-ada- adenosine deaminase
-co(n)- chondrocytes
-den- dendritic cells
-end(o)- endothelial cells
-ep(a)- hepatocytes
-fi(b)- fibroblasts
-isle- islet cells
-ker(a)- keratinocytes
-leu- lymphocytes/monocytes/ APC (white cells)
-mestro- mesenchymal stromal cells
-mio(b)- myoblasts
-ova- ovary cells
-pla(c)- placental cells
-ren- renal tubular cells
-ret- retinal cells
-tem- stem cells
-tesi- testis cells
-tu- tumor cells
-ubi- umbilical cord cells (formerly -cor-)
-ur- urothelial cells
Suffix: -cel
