News in brief - Oct. 9, 2000

Science of genetic modification not quite ready for humans

Genetic therapies that have the potential to modify an individual's inheritable genes are not yet ready to be tested in humans, according to a report released last month by the American Assn. for the Advancement of Science.

The report, produced by a 20-member panel after 21/2 years of study, concluded that inheritable genetic modifications "cannot presently be carried out safely and responsibly on humans." Specifically, the panel cites the inefficiency of gene transfer in animal studies, the potential for unintended genetic modifications and the unknown future impact.

But, even if the technological obstacles are overcome, "we would still need to determine whether these procedures offer a theologically, socially and ethically acceptable alternative to other technologies under development to treat genetic diseases," the authors state.

Further, there is a fear that the distinction between "therapeutic" and "enhancement" applications might be lost.

The report calls for creation of a federal body with authority over public and private research into human inheritable genetic modification. This body would also promote a public dialogue on the risks and benefits of this research.