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Zika Virus Resource Center

Zika virus

With global infection rates of the Zika virus increasing rapidly, physicians should be prepared to handle possible cases of the virus and answer patients’ questions. No locally-acquired vector-borne Zika virus cases have been reported in the continental United States, but cases have been confirmed in returning travelers. The AMA will update this resource center regularly to provide information to the public, physicians and other health care workers as they seek to learn more.

Updated Information

Scientists at the Centers for Disease Control and Prevention (CDC) have concluded, after careful review of existing evidence, that Zika virus is a cause of microcephaly and other severe fetal brain defects. In the report published in the New England Journal of Medicine, the CDC authors describe a rigorous weighing of evidence using established scientific criteria.

Resources for the Public

What you need to know about Zika virus
Information from the Centers for Disease Control and Prevention

Frequently asked questions about Zika virus
Videos, fact sheets and other information from the World Health Organization (WHO) that explain what the virus is, which symptoms to look for and how to protect your family

Zika virus infection, prevention and recommendations for pregnant women
Infographics, frequently asked questions, interactive games and more from the Pan American Health Organization (PAHO) and WHO

Zika and pregnancy
Latest information from the CDC for pregnant women

Information for parents about Zika virus 
Latest information from the CDC for parents

Zika virus disease 
Journal of the American Medical Association (JAMA) patient page from April 13

Zika-infected areas
World map and list of countries and territories with active Zika transmission, provided by the CDC

CDC issues advice for travel to the 2016 Summer Olympic Games
Press release from Feb. 26

Resources for Physicians

Understanding Zika Virus

Zika virus information for health care professionals
Includes clinical evaluation and diagnostic testing information from the CDC

CDC Zika Action Plan Summit 
Presentations and Resources from April 1

Zika and pregnancy 
CDC Vital Signs from April 1

Male-to-male sexual transmission of Zika virus — Texas, January 2016 
CDC Morbidity and Mortality Weekly Report (MMWRfrom April 15

Survey of blood collection centers and implementation of guidance for prevention of transfusion-transmitted Zika virus infection — Puerto Rico, 2016 
MMWR from April 15

Estimating contraceptive needs and increasing access to contraception in response to the Zika virus disease outbreak — Puerto Rico, 2016
MMWR from March 25

Travel-associated Zika virus disease cases among U.S. residents — United States, January 2015–February 2016
MMWR from March 18

Zika virus infection among U.S. pregnant travelers — August 2015–February 2016
MMWR from March 4

Transmission of Zika virus through sexual contact with travelers to areas of ongoing transmission — continental United States, 2016
MMWR from March 4

Notes from the field: Evidence of Zika virus infection in brain and placental tissues from 2 congenitally infected newborns and 2 fetal losses—Brazil, 2015 
MMWR from Feb. 10

Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy — Brazil, 2015
MMWR from March 8

Zika virus emergency preparedness and response
Latest information from the WHO

Zika virus infection
Information and resources from the PAHO and WHO

Zika virus spreads to new areas: Region of the Americas
MMWR from Jan. 22

Clinical Guidance

Zika virus—what clinicians need to know
CDC webinar from Jan. 26

CPT codes for Zika-related imaging and lab test procedures
Last updated April 15

Updated interim guidance for prevention of sexual transmission of Zika virus — United States, 2016 
MMWR from April 1

Updated interim guidance for health care providers caring for women of reproductive age with possible Zika virus exposure — United States, 2016
MMWR from March 25

Preventing transmission of Zika virus in labor and delivery settings through implementation of standard precautions — United States, 2016
MMWR from March 22

Updated interim guidelines for prevention of sexual transmission of Zika virus — United States, 2016 
CDC Health Advisory from Feb. 23

Interim guidelines for health care providers caring for infants and children with possible Zika virus infection
MMWR from Feb. 19

Recommendations for donor screening, deferral, and product management to reduce the risk of transfusion-transmission of Zika virus
FDA guidance Feb. 2016

Updated interim guidelines for health care providers caring for pregnant women and women of reproductive age with possible Zika virus exposure
MMWR from Feb. 12

Updated interim guidelines for the evaluation and testing of infants with possible congenital Zika virus infection
MMWR from Feb. 26

Interim guidelines for pregnant women during a Zika virus outbreak
MMWR from Jan. 22

Possible association between Zika virus infection and microcephaly
MMWR
 from Jan. 22

Questions and answers for health care providers caring for pregnant women and women of reproductive age with possible Zika virus exposure
CDC resource updated Feb. 9

Recognizing, managing and reporting Zika virus infections in travelers returning from Central America, South America, the Caribbean and Mexico
CDC Health Advisory from Jan. 15

Medical Journal Articles

On the seasonal occurrence and abundance of the Zika Virus vector mosquito Aedes Aegypti in the contiguous United States
PLOS Current Outbreaks published March 16

Is the United States prepared for a major Zika virus outbreak? 
JAMA Viewpoint published April 13

Zika virus 
New England Journal of Medicine (NEJM) from March 30

Pregnancy in the time of Zika: addressing barriers for developing vaccines and other measures for pregnant women
JAMA Viewpoint published March 22

Zika virus infection in pregnant women in Rio de Janeiro — preliminary report
NEJM from March 4

Infectious Zika viral particles in breast milk
Lancet Correspondence from March 1

Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study
Lancet from Feb. 26

Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study
Lancet Infectious Disease from Feb. 17

Pregnancy in the time of Zika: addressing barriers for developing vaccines and other measures for pregnant women
JAMA Viewpoint published Feb. 24

Researchers focus on solving the Zika riddles
Commentary on establishing causality, vaccine research, and containment published in JAMA Feb. 24

What pediatricians and other clinicians should know about Zika virus
JAMA Pediatrics Viewpoint published Feb. 18

Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil
Significant new clinical data on the Zika virus and infants, published online in JAMA Ophthalmology, Feb. 9

Zika virus infection and the eye
Commentary on ocular findings in infants, published online in JAMA Ophthalmology, Feb. 9

The emerging Zika pandemic: Enhancing preparedness
JAMA Viewpoint published Jan. 27

Anticipating the international spread of Zika virus from Brazil
Published in The Lancet, Jan. 23

Zika virus in the Americas—yet another arbovirus threat
Commentary published in The New England Journal of Medicine, Jan. 13 (e-publication ahead of print)

Potential sexual transmission of Zika virus
CDC Emerging Infectious Diseases dispatch from Feb. 2015

Medical Products

Zika virus response updates
Latest from FDA

FDA allows use of investigational test to screen blood donations for Zika virus
FDA press release from March 30

Occupational Exposure

Interim guidance for protecting workers from occupational exposure to Zika Virus
OSHA and NIOSH guidance from April 22

Research

Potential research priorities to inform public health and medical practice for domestic Zika virus: workshop in brief
Institute of Medicine Workshop Summary from Feb. 16

Notice of NIAID’s interest to highlight high-priority Zika virus research areas
Research notice by the National Institutes of Health from Jan. 22

Vector Control

Interim recommendations for Zika vector control in the continental United States
CDC from March 18

FDA announces comment period for draft environmental assessment for genetically engineered mosquito
FDA from March 11